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GHRP-2 – Research Use Only (RUO). Chemical reagent intended only for laboratory tests. It is not intended for human consumption or diagnostic purposes.
Related categories and reagents: In the context of this area of research, it is also worth comparing GHRP-6 and selective GH secretagogue.
GHRP-2, GHRP-6 and ipamorelin—three peptides, one receptor. All three are described as agonists of the ghrelin receptor GHS-R1a, but they differ in structure and selectivity profile. GHRP-2 is a hexapeptide with a mass of 817.97 g/mol, GHRP-6 is also a hexapeptide at 873.01 g/mol, and ipamorelin is a pentapeptide at 711.85 g/mol. The differentiating feature of ipamorelin described in the literature is signal selectivity: in vitro studies did not report increases in cortisol and prolactin to the extent described for older GHRPs. When planning an experiment on selectivity, this difference, rather than molecular mass, is relevant.
GHRP-2 (Growth Hormone Releasing Peptide-2), also known as Pralmorelin or KP-102, is a synthetic hexapeptide belonging to the group of growth hormone secretagogues (GHS). This peptide was developed in the 1990s as one of the first synthetic growth hormone secretagogue receptor (GHS-R) ligands.
GHRP-2 is the subject of intense scientific research due to its properties as an agonist of the GHS-R1a receptor (now known as the ghrelin receptor). This peptide is an important research tool in neurobiology and molecular endocrinology, used to study the mechanisms of regulation of the somatotropic axis.
GHRP-2 is a synthetic hexapeptide with the sequence D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2, which has affinity for the GHS-R1a receptor. It is one of the earliest discovered and most intensively researched peptides from the GHRP (Growth Hormone Releasing Peptides) group.
The GHS-R1a receptor to which GHRP-2 binds is the same receptor that binds endogenous ghrelin – a peptide discovered later, in 1999. This discovery allowed for a better understanding of the physiological role of the GHS-R receptor and the mechanisms of regulation of growth hormone secretion.
In a research context, GHRP-2 is used as a pharmacological tool for:
GHRP-2 is a synthetic peptide belonging to the class of growth hormone secretagogues (GHS) that act through the GHS-R1a receptor (ghrelin receptor). Unlike GHRH (Growth Hormone Releasing Hormone), which works through its own GHRH-R receptor, GHRP-2 uses an alternative mechanism of somatotrope stimulation.
| Name | Description |
|---|---|
| GHRP-2 | Growth Hormone Releasing Peptide-2 |
| Pralmorelin | International Nonproprietary Name (INN) |
| KP-102 | Code designation (Kaken Pharmaceutical) |
| GPA-748 | Alternative designation |
| Characteristic | Description |
|---|---|
| Class | Growth hormone secretagogue (GHS) |
| Target receptor | GHS-R1a (ghrelin receptor) |
| Structure | Synthetic hexapeptide |
| Origin | Synthetic (does not occur naturally) |
GHRP-2 consists of 6 amino acids, including three D-amino acids:
H-D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
Where:
Key structural features of GHRP-2:
| Parameter | Value |
|---|---|
| Summary formula | C45H55N9O6 |
| Molar mass | 817.97 g/mol |
| CAS number | 158861-67-7 |
| Number of amino acids | 6 |
| C-end | Amidated (-NH2) |
| Solubility | Soluble in water and DMSO |
| Form | Freeze-dried powder (white) |
| UV absorption | Maximum at 280 nm (Trp) |
| Characteristic | GHRP-2 | GHRP-6 |
|---|---|---|
| Sequence | D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys | His-D-Trp-Ala-Trp-D-Phe-Lys |
| Molar mass | 817,97 | 873,01 |
| Amino acid item 1 | D-Ala | His |
| Amino acid position 2 | D-2Nal | D-Trp |
Quality parameters:
| Test | Method | Specification |
|---|---|---|
| Cleanliness | HPLC | ≥98% |
| Identification | MS | 817.97 ± 0.5 Da |
| Water content | Karl Fischer | ≤8% |
| Acetate content | Titration | ≤12% |
| Appearance | Visual | White lyophilisate |
| Solubility | Test | Clear in water |
Reverse Phase HPLC:
– UV detection at 280 nm (tryptophan)
– C18 column, ACN/H2O gradient
– Separation from isomers and degradation products
Mass spectrometry:
– ESI-MS to confirm molar mass
– MS/MS for sequence verification
Freeze-dried form:
– Temperature: -20°C (optimal)
– Permissible: 2-8°C (short term)
– Protect from light (tryptophan)
– Shelf life: 24 months at -20°C
After reconstitution:
– Solvent: sterile water or bacteriostatic water
– Storage: 2-8°C
– Use within 14 days
– Possibility to freeze aliquots
GHRP-2 is being studied as an agonist of the GHS-R1a receptor, which belongs to the G protein-coupled receptor (GPCR) family. In vitro tests analyze:
Receptor binding:
– Affinity (Ki) for GHS-R1a
– Selectivity towards other GPCRs
– Binding kinetics
Signal transduction:
– Activation of the Gq/11 protein
– Phospholipase C and IP3 production
– Release of calcium from the reticulum
– PKC activation
The literature describes the use of GHRP-2 in research on:
| Parameter | GHRP-2 | Ghrelin |
|---|---|---|
| Type | Synthetic | Endogenous |
| Structure | Hexapeptide | 28 AA + acyl |
| Receptor | GHS-R1a | GHS-R1a |
| Modification | Lack | Ser3 octanoylation |
IMPORTANT: The product is intended for in vitro testing only. Not intended for:
– Use in humans or animals
– Diagnostic or therapeutic purposes
– Application in sports
GHRP-2 (Pralmorelin) is a synthetic hexapeptide that is an agonist of the GHS-R1a receptor (ghrelin receptor). Thanks to its well-understood structure, high purity and receptor selectivity, it is a valuable tool in molecular endocrinology and neurobiology research.
One Peptides GHRP-2 5 mg material offers:
Growth Hormone Releasing Peptide-2 is a synthetic hexapeptide with the sequence D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2 and a molar mass of 817.97 g/mol. It contains three D-amino acids and the unnatural amino acid D-2-naphthylalanine. It is an agonist of the GHS-R1a receptor (ghrelin receptor). The CAS number is 158861-67-7.
GHRP-2 and GHRP-6 are both hexapeptides that act on the GHS-R1a receptor, but they differ in their amino acid sequence. GHRP-2 has D-2-naphthylalanine at position 2 and D-alanine at position 1, while GHRP-6 has D-tryptophan at position 2 and histidine at position 1. GHRP-2 has a mass of 817.97 g/mol and GHRP-6 has a mass of 873.01 g/mol.
In freeze-dried form, GHRP-2 is stored at -20°C, protected from light (due to tryptophan). After reconstitution in sterile water, the solution is stored at 2-8°C and used within 14 days. It is possible to freeze small portions for longer storage.
GHS-R1a (Growth Hormone Secretagogue Receptor type 1a) is a G protein-coupled receptor that binds both endogenous ghrelin and synthetic GH secretagogues, including GHRP-2. This receptor is expressed mainly in the pituitary gland and hypothalamus, but also in other tissues.
GHRP-2 is used in in vitro studies regarding: characterization of the GHS-R1a receptor, intracellular signaling mechanisms, structure-activity studies of GH secretagogues and comparisons with other receptor ligands (ghrelin, GHRP-6, Ipamorelin). It is not intended for use on humans or animals.
The most important features of the ONE GHRP-2 5 mg product:
Research context: see the overview what research says about GHRP-2 and GHRP-6 in the context of laboratory research and RUO framing.
Parent category: Peptides for Regeneration organize RUO reagents associated with recovery-related research contexts.
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