SARMs in Kapseln

SARMs and modulators in capsule format are Research Use Only chemical reagents intended exclusively for laboratory studies. A capsule is a packaging format and does not change the regulatory status of the substance. These materials are not dietary supplements, medicines, or products intended for human use.

Research Use Only. Products in this category are chemical substances intended exclusively for laboratory and scientific research. They are not dietary supplements, medicines, food products, or materials intended for consumption or administration to humans or animals. The descriptions refer to pharmacology and findings reported in the scientific literature; they are not advice or instructions for use.

Capsule format is a form, not a regulatory class

A capsule, a lyophilised vial, and a solution are physical forms of a reagent, not separate legal categories. Regulatory class follows the substance rather than the package. The same substance in a capsule and a vial remains within the same Research Use Only framework.

Capsule packaging divides research material into repeatable units and can simplify batch records and analytical handling. It is not a statement of intended use. A reagent in a capsule remains a reagent and is not intended for consumption.

SARMs in a research context

A selective androgen receptor modulator binds to the androgen receptor and can produce a different receptor conformation and cofactor-recruitment pattern from endogenous androgens. Tissue selectivity reported in preclinical systems is model-dependent, and translation to predictable human outcomes remains uncertain.

Reagents available in capsule format

• Ostarine (MK-2866) is the most extensively studied SARM and has phase III clinical-development data.
• LGD-4033 (ligandrol) has phase I data and published case reports of drug-induced liver injury.
• Andarine (S4) is an early non-steroidal SARM studied mainly in rodents; reversible visual disturbances are a recognised signal.
• RAD-140 (testolone) has preclinical androgen-receptor data and published liver-injury case reports.
• YK-11 has a steroidal scaffold and an evidence base limited to cell culture.
• Cardarine (GW-501516) is a PPARδ agonist and not a SARM. Long-term rodent studies produced a carcinogenicity signal.

A broader classification of SARMs and compounds with other molecular targets is available in SARMs and modulators.

Research areas

• models of muscle loss and sarcopenia;
• bone mineral density and mechanical parameters in animal models;
• androgen-receptor binding and cofactor recruitment;
• early-phase pharmacokinetic characterisation.

Safety signals reported in the literature

• suppression of endogenous testosterone;
• reduced HDL and other lipid-profile changes;
• drug-induced liver injury reports for some compounds;
• visual disturbances associated with andarine;
• the cardarine carcinogenicity signal in rodent studies;
• lack of long-term safety data and, for YK-11, lack of animal and human data.

No SARM in this category is approved as a medicinal product by the EMA or FDA.

Research reagent quality

• HPLC purity ≥98%;
• identity confirmation by mass spectrometry;
• batch-specific certificate of analysis with declared capsule content;
• batch traceability;
• storage in the original container in a cool, dry place protected from light and moisture.

Regulatory and WADA status

These materials are Research Use Only reagents. WADA lists SARMs including ostarine, LGD-4033, andarine, RAD-140, and YK-11 under S1 and cardarine under S4. Sensitive methods have been developed to detect these compounds and their metabolites.

Frequently asked questions

Does a capsule mean that the product is a dietary supplement?

No. Capsule format is solely a method of packaging a reagent. Regulatory class follows the substance, not the package. The same substance in a capsule and a vial remains Research Use Only and is not intended for consumption.

How do SARMs in capsules differ from SARMs in another format?

Only in packaging format. The substance, purity, and regulatory status remain the same and are confirmed by the certificate of analysis assigned to the batch.

Are all compounds in this category SARMs?

No. Cardarine (GW-501516) is a PPARδ agonist and not a SARM, although it is often grouped with them. YK-11 is also a distinct case because it acts through the androgen receptor but has a steroidal scaffold and is described as a steroidal AR modulator.

Can these reagents be detected in anti-doping control?

Yes. SARMs are included in WADA category S1 and cardarine in category S4. Sensitive detection methods exist for these compounds and their metabolites.