GW-501516 Cardarine

GW-501516 Cardarin – PPARδ agonist for metabolic studies

GW-501516 (Cardarine, Cardarine) is a small molecule that is an agonist of the PPARδ receptor (peroxisome proliferator-activated receptor delta). Contrary to common misconception, GW-501516 is not a SARM – it is a nuclear receptor ligand with a different mechanism of action. In studies on cellular and animal models, it shows activity that modulates the oxidation of fatty acids and the expression of genes related to energy metabolism. CAS: 317318-70-0. GW-501516 is not a medicinal product – it is intended for research use only. Browse the available variants in the One Peptides offer.

What is GW-501516?

GW-501516, also known as Cardarine or Cardarine, is a synthetic ligand of the PPARδ receptor (peroxisome proliferator-activated receptor delta) – one of three isoforms of receptors activated by peroxisome proliferators. This compound was originally developed in collaboration between GlaxoSmithKline and Ligand Pharmaceuticals in the 1990s.

The mechanism of action of GW-501516 involves binding to the PPARδ receptor, which functions as a transcription factor. Once activated, PPARδ regulates the expression of genes involved in fatty acid transport and beta-oxidation, mitochondrial biogenesis, and lipid metabolism. In studies on muscle cells, an increase in the expression of genes responsible for the oxidation of fatty acids, such as CPT1 and ACOX1, was observed.

GW-501516 is a small organic molecule (not a peptide), which distinguishes it from many other compounds in the One Peptides offer. Its molecular weight is approximately 453.5 g/mol and its CAS number is 317318-70-0. As a research compound, it does not have the status of a medicinal product.

GW-501516 variants available

The product is supplied with a Certificate of Analysis (CoA) confirming the purity and identity of the compound. Detailed specifications are available on the product card.

Which GW-501516 variant should I choose?

One Peptides offer includes one variant, GW-501516 – capsules containing 10 mg of cardarine in a package of 60 pieces. This form is suitable both for initial in vitro studies (e.g. PPARδ activation tests in cell cultures, target gene expression assays) and for extended protocols in animal models.

The product has purity parameters confirmed by independent HPLC and MS analysis.

How does GW-501516 differ from similar compounds?

GW-501516 vs SR-9009 (Stenabolic)
Both compounds are studied in the context of energy metabolism, but they act on different molecular targets. GW-501516 activates the PPARδ receptor, which regulates the expression of genes related to fatty acid oxidation. SR-9009, on the other hand, is an agonist of the Rev-ErbA receptor – a nuclear receptor involved in the regulation of circadian rhythm and mitochondrial biogenesis. In studies on cell models, it was observed that both compounds influence energy metabolism, but through different signaling pathways and with different modulated gene profiles. You can find more about SR-9009 in the category SR-9009 Stenabolic.

GW-501516 vs MK-677 (Ibutamoren)
This comparison concerns compounds with completely different mechanisms. GW-501516 is a ligand of the nuclear receptor PPARδ and directly modulates metabolic gene expression. MK-677, on the other hand, is an agonist of the ghrelin receptor (GHS-R1a) and affects the GH/IGF-1 axis, stimulating the release of growth hormone in endocrine models. These two compounds therefore operate at different levels of metabolic regulation. Check the category MK-677 Ibutamoren.

FAQ – Frequently asked questions

1. Is GW-501516 a SARM?
NO. GW-501516 is not a selective androgen receptor modulator (SARM). It is an agonist of the PPARδ receptor – a nuclear receptor from the PPAR family. It does not bind to the androgen receptor and works through a completely different mechanism than SARMs such as MK-2866.

2. What is the mechanism of action of GW-501516 at the cellular level?
GW-501516 binds to the PPARδ receptor, which upon activation forms a heterodimer with the RXR receptor and binds to PPAR response elements (PPRE) in the promoters of target genes. The effect is a change in the expression of genes related to the transport and oxidation of fatty acids.

3. Is GW-501516 a medicinal product?
NO. GW-501516 offered by One Peptides is a compound intended solely for research purposes (Research Use Only). It is not a medicine, dietary supplement or product intended for use on humans.

4. Which research models use GW-501516?
GW-501516 is used in studies on cell lines (e.g. C2C12 myotubes, hepatocytes), animal models and in PPARδ activation reporter tests. It serves as a tool to study the metabolic pathways regulated by this receptor.

5. How to store GW-501516?
GW-501516 should be stored in a dry, dark place, at room temperature or lower, according to the guidelines on the product card. Tightly closing the packaging protects the compound against moisture and degradation.

Quality and standards at One Peptides

Each batch of GW-501516 at One Peptides is verified by HPLC (purity) and mass spectrometry (MS, molecular weight confirmation). Each order is accompanied by a certificate of analysis (CoA) and a safety data sheet (SDS). Quality control also includes verifying the identity of the compound against a reference standard.