In brief. MK-2866 (ostarine, enobosarm) is a selective androgen receptor modulator (SARM) that binds the androgen receptor with preference for muscle and bone tissue, unlike systemically active steroidal androgens. This category contains one variant: 10 mg in 60 capsule units, with chromatographic purity of ≥98% and a COA for every batch. Ostarine is not approved as a medicine or dietary supplement and is included on the WADA Prohibited List (category S1). All items in this category are chemical reagents intended only for laboratory research (RUO).
MK-2866 (Ostarine, Ostarine) is a selective androgen receptor modulator (SARM) – a small organic molecule that binds to the androgen receptor (AR) with high affinity and tissue selectivity. In vitro and in animal models, MK-2866 shows activity in muscle and bone cells, with limited effects on other androgen-dependent tissues. CAS: 841205-47-8. MK-2866 is not a medicinal product – it is intended for research use only. Browse available Ostarine variants from One Peptides.
MK-2866, known as Ostarine (Ostarine) or Enobosarm, is a selective androgen receptor modulator (SARM) developed by GTx Inc. It is a small organic molecule from the arylpropionamide group, designed to selectively bind to the androgen receptor (AR) in specific types of tissues.
Unlike classic AR ligands, MK-2866 shows tissue selectivity in experimental models – it activates the androgen receptor mainly in muscle and bone cells, with a limited effect on tissues such as the prostate or sebaceous glands. This selectivity is due to the different conformation of the AR-ligand complex and the differential recruitment of transcription cofactors in different cell types.
The mechanism of action of MK-2866 includes binding to the LBD (ligand-binding domain) of the androgen receptor, which leads to its translocation to the cell nucleus, dimerization and binding to androgen response elements (AREs) in the promoters of target genes. In studies on cell lines, modulation of the expression of genes related to muscle protein synthesis was observed. The CAS number of MK-2866 is 841205-47-8.
| Variant | Form | Research use |
|---|---|---|
| MK-2866 Ostarine 10 mg 60 capsules | Kapseln | Androgen receptor binding studies |
The product is supplied with a Certificate of Analysis (CoA) confirming purity and identity. HPLC and MS analysis results are available on the product card.
One Peptides offer includes one variant, MK-2866 – capsules containing 10 mg of Ostarine in a package of 60 pieces. This form is suitable for both in vitro studies (androgen receptor binding tests, transcription activation assays, tissue selectivity studies on cell lines) and for extended protocols on animal models.
The product has purity parameters confirmed by independent HPLC and MS analyses.
MK-2866 vs MK-677 (Ibutamoren)
Despite similar designations (MK-), these are compounds with completely different mechanisms of action. MK-2866 is a selective androgen receptor modulator (SARM) – it binds to AR and modulates the transcription of androgen-dependent genes. MK-677 is an agonist of the ghrelin receptor (GHS-R1a) and affects the release of growth hormone. It does not bind to the androgen receptor. These two compounds act on completely different signaling pathways. You can find more about MK-677 in the category MK-677 Ibutamoren.
MK-2866 vs GW-501516 (Cardarine)
MK-2866 works by modulating the androgen receptor in muscle and bone cells, while GW-501516 activates the PPARδ receptor – a nuclear receptor that regulates the expression of fatty acid metabolism genes. The first relationship concerns androgenic pathways, the second – metabolic pathways. In studies on animal models, it was observed that their action profiles are complementary, but based on different molecular targets. Check the category GW-501516 Cardarine.
MK-2866 vs SR-9009 (Stenabolic)
SR-9009 is an agonist of the Rev-ErbA receptor, involved in the regulation of circadian rhythm and mitochondrial biogenesis. Unlike MK-2866, which modulates androgen receptor activity, SR-9009 does not affect androgen pathways. Both compounds are small organic molecules, but they differ in both their molecular target and the profile of the genes they modulate. Category SR-9009 Stenabolic.
1. What does the abbreviation SARM mean in the context of MK-2866?
SARM is a selective androgen receptor modulator. This term means that the compound binds to the androgen receptor, but in a tissue-selective manner – it activates it preferentially in specific cell types, which distinguishes it from classic androgens.
2. Is MK-2866 a steroid?
NO. MK-2866 is not an anabolic-androgenic steroid. It is a small organic molecule from the arylpropionamide group that modulates the androgen receptor in a tissue-selective manner. Structurally and pharmacologically, it differs from steroids.
3. Is MK-2866 a medicinal product?
NO. MK-2866 offered at One Peptides is a compound intended solely for research purposes (Research Use Only). It is not a medicine, dietary supplement or agent intended for use on humans.
4. What experimental models is MK-2866 being tested in?
MK-2866 is used in androgen receptor binding tests, transcription activation studies (reporter tests), experiments on muscle and bone cell lines (e.g. C2C12, MC3T3-E1) and in animal models to assess tissue selectivity.
5. How to store MK-2866?
MK-2866 should be stored in a dry, dark place at room temperature or lower. The package should be tightly closed to protect the compound from moisture. Detailed guidelines can be found on the product card and in the SDS.
Each batch of MK-2866 at One Peptides is subjected to HPLC analysis (purity) and mass spectrometry (MS, confirmation of molecular weight and identity). We attach a certificate of analysis (CoA) and a safety data sheet (SDS) to each order. Quality standards include verification of each batch before release for sale.
We offer a wide selection of peptides tailored to a range of laboratory analytical needs.
Every batch is tested for identity and purity (HPLC, MS) and comes with a certificate of analysis.
We invest in analytical testing and full batch documentation for every product.
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