Ipamorelin 2 mg | One Peptides

Name: IPAMORELIN 2 mg
Brand: One-Peptides
SKU: OP-000008
Price: 26 EUR
Availability: InStock

One Peptides Ipamorelin 2 mg – chemical reagent for laboratory tests

Ipamorelin – Research Use Only (RUO). Chemical reagent intended only for laboratory tests. It is not intended for human consumption or diagnostic purposes.
Related categories and reagents: In the context of this area of research, it is also worth comparing CJC without DAC and GHRP-6.

Ipamorelin vs GHRP-6. Both are agonists of the ghrelin receptor GHS-R1a, but ipamorelin is a pentapeptide (711.85 g/mol), whereas GHRP-6 is a hexapeptide (873.01 g/mol). Ipamorelin’s research identity is based on selectivity: in vitro studies did not report increases in cortisol and prolactin to the extent described for older GHRPs. This is why the literature sometimes selects it as a tool for isolating GHS-R1a signaling.

Ipamorelin vs CJC-1295 without DAC. Different receptors: CJC-1295 (3,367.9 g/mol) is a GHRH analogue described in relation to GHRH-R. Comparisons of the two in the literature result from their representing two independent entry points into the growth hormone axis, not from molecular similarity.

Introduction and research framework

Ipamorelin is a synthetic pentapeptide belonging to the third generation of growth hormone secretagogues (GHS). This peptide was developed by Novo Nordisk in the 1990s as a highly selective agonist of the GHS-R1a receptor (ghrelin receptor), distinguished by minimal impact on other hormonal systems.

Compared to previous GH secretagogues, such as GHRP-6 or GHRP-2, Ipamorelin is characterized by greater receptor selectivity. This property makes it a valuable tool in the study of specific ghrelin receptor signaling mechanisms, without interfering effects on other hormonal pathways.

General characteristics of the Ipamorelin compound

Ipamorelin is a pentapeptide with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH2, containing unnatural amino acids that give it increased stability and selectivity. It is one of the newest peptides in the GHS series, designed to maximize selectivity towards the GHS-R1a receptor.

Key features of Ipamorelinau as a research tool:

High selectivity towards GHS-R1a
No effect on other pituitary hormones (in in vitro models)
Presence of unnatural amino acids
Good metabolic stability

The One Peptides Ipamorelin 2 mg material is supplied in the form of a high-purity lyophilized powder, intended for use in biochemical and pharmacological research.

What is Ipamorelin?

Ipamorelin is a synthetic peptide belonging to the class of growth hormone secretagogues (GHS), designed as a highly selective agonist of the GHS-R1a receptor. Unlike previous GHRPs, Ipamorelin does not show significant affinity for opioid receptors or influence the secretion of cortisol or prolactin in in vitro tests.

Nomenclature and Synonyms

Name	Description
Ipamorelin	Common name
NNC 26-0161	Code designation Novo Nordisk
Ipamorelin acetate	Acetate salt form

Classification

Characteristic	Description
Class	Growth hormone secretagogue (GHS)
Generation	3rd generation GHRP
Target receptor	GHS-R1a (ghrelin receptor)
Structure	Synthetic pentapeptide
Selectivity	High for GHS-R1a

GHS Generation Comparison

Generation	Examples	Characteristics
AND	GHRP-6	Low selectivity
II	GHRP-2, Hexarelin	Average selectivity
III	Ipamorelin	High selectivity

Structure and physicochemical properties

Amino Acid Sequence

Ipamorelin consists of 5 amino acids, including two unnatural ones:

H-Aib-His-D-2Nal-D-Phe-Lys-NH2

Where:

Aib – 2-aminoisobutyric acid (α-aminoisobutyric acid)
His – L-histidine
D-2Nal – D-2-naphthylalanine
D-Phe – D-phenylalanine
Lys – L-lysine (C-terminus amidated)

Characteristics of Amino Acids

Position 1 (Aib) – unnatural amino acid, stabilizes conformation
Position 2 (His) – L-histidine, a basic amino acid
Position 3 (D-2Nal) – D-2-naphthylalanine, a large aromatic amino acid
Position 4 (D-Phe) – D-phenylalanine, D configuration
Position 5 (Lys) – L-lysine, C-terminus amidated

Physicochemical properties

Parameter	Value
Summary formula	C38H49N9O5
Molar mass	711.85 g/mol
CAS number	170851-70-4
Number of amino acids	5
C-end	Amidated (-NH2)
Unnatural amino acids	2 (Aib, D-2Nal)
Solubility	Soluble in water
Form	Freeze-dried powder (white)

Comparison with Other GHS

Peptide	Sequence	Mass (g/mol)	Selectivity
Ipamorelin	Aib-His-D-2Nal-D-Phe-Lys	711,85	High
GHRP-2	D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys	817,97	Mean
GHRP-6	His-D-Trp-Ala-Trp-D-Phe-Lys	873,01	Low
Hexarelin	His-D-2MeTrp-Ala-Trp-D-Phe-Lys	887,04	Mean

Purity, identification and quality control

Product Specification ONE Ipamorelin 2 mg

Quality parameters:

Test	Method	Specification
Cleanliness	HPLC	≥98%
Identification	MS	711.85 ± 0.5 Da
Water content	Karl Fischer	≤8%
Acetate content	Titration	≤12%
Appearance	Visual	White lyophilisate
Solubility	Test	Clear in water

Storage and laboratory handling

Ipamorelin Storage Conditions

Freeze-dried form:
– Temperature: -20°C (optimal)
– Permissible: 2-8°C (up to 1 month)
– Protect from light and moisture
– Shelf life: 24 months at -20°C

After reconstitution:
– Solvent: sterile water or bacteriostatic water
– Storage: 2-8°C
– Use within 14-21 days
– Possibility to freeze aliquots

Reconstitution Instructions

Equalize the temperature of the vial (15-20 min)
Add the solvent slowly along the wall
Recommended concentration: 1-2 mg/ml
Rotate gently – do not vortex
The solution should be clear
Store in the refrigerator

Ipamorelin stability

Ipamorelin shows good stability due to:

Presence of Aib (increases resistance to proteases)
D-amino acids (D-2Nal, D-Phe)
C-terminal amidation

Mechanism of action at the molecular level

GHS-R1a receptor

Ipamorelin is being investigated as a selective GHS-R1a receptor agonist. In vitro tests analyze:

Binding characteristics:
– High affinity for GHS-R1a
– Low activity against other GPCRs
– Comparison with ghrelin and other GHSs

Selectivity:

Receptor/Parameter	Ipamorelin	GHRP-6
GHS-R1a	+++	+++
Opioid receptors	±	++
ACTH (in vitro)	–	+
Prolactin (in vitro)	–	+

Intracellular Signaling

In studies on cell cultures expressing GHS-R1a:

Activation of the Gq/11 pathway
IP3 production
Intracellular Ca2+ release
PKC activation

Comparative Research

Ipamorelin is often compared with:

GHRP-2 and GHRP-6
Hexarelin
Ghrelin (endogenous ligand)
MK-677 (ghrelin mimetic, non-peptide)

Ipamorelin – Applications in Scientific Research

Receptor Research

GHS-R1a characteristics without off-target effects
Selective activation of the signaling pathway
Comparison with non-selective agonists
Structure-activity studies

Pharmacological Research

GHS-R1a selective activation model
Comparison of activity profiles of different GHSs
Dose-response studies
Kinetics of receptor-ligand binding

Signaling Research

Downstream pathways selectively activated
Comparison with non-selective agonists
Mechanisms of receptor desensitization
GHS-R1a internalization

Peptide Biochemistry

Effect of Aib on conformation and stability
The importance of D-amino acids
Selectivity optimization by structural modifications

Reservations

IMPORTANT: The product is intended for in vitro testing only. Not intended for:
– Use in humans or animals
– Diagnostic or therapeutic purposes
– Application in sports

Summary

Ipamorelin is a synthetic pentapeptide of the third generation of growth hormone secretagogues, characterized by high selectivity towards the GHS-R1a receptor. The presence of unnatural amino acids (Aib, D-2Nal) ensures good stability and unique pharmacological properties, making it a valuable tool in research on the selective activation of the ghrelin receptor.

Material One Peptides Ipamorelin 2 mg offers:

High purity ≥98% HPLC
Full spectrometric characterization
Stable freeze-dried form
Certificate of analysis for each batch

Ipamorelin – Scientific FAQ

1. What is Ipamorelin and what is its structure?

Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH2, containing two unnatural amino acids (Aib and D-2-naphthylalanine). The molar mass is 711.85 g/mol and the CAS number is 170851-70-4. It is a third-generation selective GHS-R1a receptor (ghrelin receptor) agonist.

2. How is Ipamorelin different from other GH secretagogues?

Ipamorelin is characterized by high selectivity towards the GHS-R1a receptor. Unlike GHRP-6 or GHRP-2, in vitro studies show no significant activity towards opioid receptors or influence the secretion of cortisol and prolactin. This makes it a useful tool for examining the specific effects of GHS-R1a activation.

3. How to store Ipamorelin?

In freeze-dried form, Ipamorelin is stored at -20°C, protected from light and moisture. Due to the presence of Aib and D-amino acids, it is relatively stable. After reconstitution in sterile water, the solution is stored at 2-8°C for up to 14-21 days or frozen in small portions.

4. What does the abbreviation “Aib” mean in the sequence?

Aib is 2-aminoisobutyric acid (α-aminoisobutyric acid) – an unnatural amino acid with two methyl groups on the α carbon. Its presence in the N-terminal position increases the stability of the peptide towards aminopeptidases and influences the conformation of the peptide chain, promoting a helical structure.

5. What tests is Ipamorelin used for?

Ipamorelin is used in in vitro studies as a tool to selectively activate the GHS-R1a receptor. Applications include: receptor studies, signaling pathway analyses, comparisons with other GH secretagogues, and structure-activity studies. It is not intended for use on humans or animals.

The most important research conclusions

The most important features of the ONE Ipamorelin 2 mg product:

Type – 3rd generation GH secretagogue
Sequence – Aib-His-D-2Nal-D-Phe-Lys-NH2
Molar mass – 711.85 g/mol
CAS number – 170851-70-4
Receptor – GHS-R1a (high selectivity)
Cleanliness – minimum 98% HPLC
Form – lyophilisate (white powder)
Unnatural amino acids – Aib, D-2Nal
Destiny – only in vitro tests

Bibliography

Raun K, et al. (1998) “Ipamorelin, the first selective growth hormone secretagogue” – European Journal of Endocrinology, 139(5):552-561.
Link: https://pubmed.ncbi.nlm.nih.gov/9849822/
Anderson LL, et al. (2001) “Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats” – Growth Hormone & IGF Research, 11(1):14-18.
Link: https://pubmed.ncbi.nlm.nih.gov/11437469/
Hansen BS, et al. (1999) “The growth hormone secretagogue receptor: pharmacological and physiological aspects” – Growth Hormone & IGF Research, 9 Suppl A:33-39.
Link: https://pubmed.ncbi.nlm.nih.gov/10429878/