SR-9009 Stenabolic

SR-9009 Stenabolic – Rev-ErbA agonist for metabolism and circadian rhythm studies

SR-9009 (Stenabolic) is a synthetic agonist of the Rev-ErbA nuclear receptor – a small molecule modulator involved in the regulation of circadian rhythm, mitochondrial biogenesis and energy metabolism at the cellular level. SR-9009 is not a SARM – it does not affect the androgen receptor. It is a small organic molecule studied in the context of metabolic pathways and the biological clock. CAS: 1379686-30-2. SR-9009 is not a medicinal product – it is intended for research use only. Browse available Stenabolic variants from One Peptides.

What is SR-9009?

SR-9009, known under the trade name Stenabolic, is a synthetic agonist of the Rev-ErbAα and Rev-ErbAβ nuclear receptors. This compound was developed by Professor Thomas Buris at the Scripps Research Institute and first described in the scientific literature in 2012.

Rev-ErbA receptors belong to the nuclear receptor superfamily and function as transcriptional repressors. They play an important role in regulating the circadian clock (circadian rhythm), controlling the expression of the BMAL1 and CLOCK genes – the central components of the molecular circadian oscillator. SR-9009, by activating Rev-ErbA, enhances the repression of these target genes.

In addition to regulating the circadian rhythm, Rev-ErbA participates in the control of mitochondrial biogenesis, lipid metabolism, fatty acid oxidation and the inflammatory response. In studies on cellular and animal models, it was observed that SR-9009 modulated the expression of genes related to these processes. SR-9009 is a small organic molecule with a molecular weight of approximately 437.9 g/mol and a CAS number of 1379686-30-2. It is not a peptide or SARM.

SR-9009 variants available

The product is accompanied by a certificate of analysis (CoA) confirming the purity and identity of the compound. Full specifications are available on the product card.

Which SR-9009 variant should you choose?

One Peptides offer includes one variant of SR-9009 – capsules containing 10 mg in a package of 60 pieces. This form is suitable for both in vitro studies (Rev-ErbA activation tests in cell lines, circadian clock gene expression assays, mitochondrial biogenesis studies) and extended protocols on animal models with repeated administration and monitoring of metabolic parameters.

The product has purity and quality parameters confirmed by independent analyses.

How is SR-9009 different from similar compounds?

SR-9009 vs GW-501516 (Cardarine)
Both compounds are studied in the context of energy metabolism, but act through different molecular targets. SR-9009 activates Rev-ErbA receptors – transcriptional repressors involved in the regulation of circadian rhythm and mitochondrial biogenesis. GW-501516 is an agonist of the PPARδ receptor, which activates the transcription of genes related to fatty acid oxidation. In studies on cell models, both compounds were observed to influence the metabolic profile of cells, but modulate different sets of target genes. The SR-9009 also has a distinct cirkadian control component, which the GW-501516 does not have. More about GW-501516 in the category GW-501516 Cardarine.

SR-9009 vs MK-2866 (Ostarine)
This comparison concerns two compounds with completely different mechanisms. SR-9009 is a modulator of Rev-ErbA receptors and does not affect androgen pathways. MK-2866 is a selective androgen receptor modulator (SARM) – it binds to AR and regulates the expression of androgen-dependent genes in muscle and bone cells. These compounds operate at different levels of cell biology and are used in different research models. Check the category MK-2866 Ostarine.

FAQ – Frequently asked questions

1. Is SR-9009 a SARM?
NO. SR-9009 is not a selective androgen receptor modulator. It does not bind to the androgen receptor. It is an agonist of Rev-ErbA nuclear receptors, which function as transcriptional repressors involved in the regulation of circadian rhythm and metabolism.

2. What is the Rev-ErbA receptor?
Rev-ErbA (Rev-ErbAα and Rev-ErbAβ) are nuclear receptors from the nuclear receptor superfamily that act as transcriptional repressors. They are key components of the molecular circadian clock and regulate the expression of genes related to lipid metabolism, mitochondrial biogenesis and the inflammatory response.

3. Is SR-9009 a medicinal product?
NO. SR-9009 offered at One Peptides is a compound intended solely for research purposes (Research Use Only). It is not a medicine, dietary supplement or product for use on humans.

4. What research models use SR-9009?
SR-9009 is used in studies on cell lines (e.g. hepatocytes, myocytes, macrophages) to study the regulation of circadian rhythm, mitochondrial biogenesis and lipid metabolism. It is also used in animal models to assess the impact of Rev-ErbA modulation on metabolic parameters.

5. How to store SR-9009?
SR-9009 should be stored in a dry, dark place, at room temperature or lower, in a tightly closed container. Detailed guidelines regarding storage conditions are provided on the product card and in the safety data sheet (SDS).

Quality and standards at One Peptides

Each batch of SR-9009 is analyzed by HPLC (purity) and mass spectrometry (MS, molecular weight confirmation). Each order is accompanied by a certificate of analysis (CoA) and a safety data sheet (SDS). Quality control includes verification of identity and purity before a batch is released for distribution.