Physiotherapist with 20 years of clinical experience, graduate of Poznan University of Medical Sciences. Founder of One Peptides and lead author of clinical-perspective content.
In the 1970s and 1980s, the Russian school of peptidology developed in parallel with—and often independently of—mainstream Western neuropharmacology. Research teams at the Institute of Molecular Genetics of the Russian Academy of Sciences and the Institute of Experimental Pharmacology in Moscow worked on a strategy that would only begin to be explored in Western pharmacology a decade later: take short, biologically […]
In 1953, the American biochemist Vincent du Vigneaud from Cornell University published a paper in the Journal of the American Chemical Society that won him the Nobel Prize in Chemistry two years later. Du Vigneaud chemically synthesized the first hormonal peptide, oxytocin. Success was not a minor laboratory achievement; this was historical validation of the concept that small peptide molecules could […]
GLP-1, GIP, glucagon – how do incretins work in regulating metabolism In 1964, two research teams independently observed a phenomenon that at first glance seemed to be a measurement anomaly. Glucose given orally to a healthy person caused a much greater insulin release than the same dose of glucose given intravenously – at the same blood glucose level. The difference is not […]
Two peptides from the same broad pharmacological class – incretin agonists – but two completely different molecule design philosophies. Semaglutide, developed by Denmark’s Novo Nordisk and launched in 2017, is a GLP-1 receptor monoagonist – a continuation of the lineage previously started by liraglutide, exenatide and lixisenatide. The design assumption was conservative: take a proven mechanism (activation of one […]
The peptide calculator helps you avoid mistakes when working with research peptides. The most common error is not a reconstitution error or a storage error. The most common error is an arithmetic error – confusion between milligrams and micrograms, between milliliters and “units” on an insulin syringe, between mass concentration and molar concentration. It rarely costs the health of the sample and often the precision of the experiment – which […]
The certificate of peptide analysis usually comes to you as a one-page PDF file or paper scan. At first glance – a few logos, a table with numbers, percentage of purity next to the HPLC heading, somewhere below the mass spectrum or its numerical representation. Most researchers only look at one number: purity. If they see “≥98%”, they consider it resolved and proceed to […]
The most common misunderstanding when working with research peptides isn’t about reconstitution or dosing – it’s about storage. In the laboratory, you can find vials of BPC-157 left on the counter over the weekend, ampoules of TB-500 repeatedly frozen and thawed during the experiment, and semaglutide stored for a year in the refrigerator door next to the milk. Each of these cases is an error that will not be revealed […]
You’ve been training for months. You maintain your calorie deficit with surgical precision. The fat comes off the arms, chest, legs – but the lower belly and side folds stubbornly resist the granite wall. It’s not a matter of discipline or genetics in the common sense. It’s a receptor issue: fat cells in these “resistant” areas have more alpha-2 adrenergic receptors than the rest of the body. And […]
Two molecules. Two fundamentally different approaches to the same hormonal axis. MK-677 tells the pituitary gland to “produce more growth hormone.” HGH Fragment 176-191 tells fat tissue to “act as if you were getting growth hormone – without the rest of its effects.” One stimulates the endogenous production of the entire hormone. The second provides an isolated fragment responsible for one specific action. Which of these mechanisms […]
It’s 3 a.m. Your brain produces melatonin, your intestines slow down your peristalsis, your body temperature drops to a minimum. Every cell in the body “knows” that it is night – and behaves accordingly. This internal schedule is the biological clock: a network of feedbacks between clock genes that synchronizes metabolism, immunity, regeneration and sleep with the day-night cycle. What if […]
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