{"id":1005,"date":"2024-11-23T08:19:01","date_gmt":"2024-11-23T08:19:01","guid":{"rendered":"https:\/\/one-peptides.com\/product\/ipamorelin-2mg\/"},"modified":"2026-09-29T17:06:42","modified_gmt":"2026-09-29T17:06:42","slug":"ipamorelin-2mg","status":"publish","type":"product","link":"https:\/\/one-peptides.com\/es\/producto\/ipamorelin-2mg\/","title":{"rendered":"IPAMORELIN 2 mg"},"content":{"rendered":"

One Peptides Ipamorelin 2 mg – chemical reagent for laboratory tests<\/strong><\/h2>\n

Ipamorelin – Research Use Only (RUO). Chemical reagent intended only for laboratory tests. It is not intended for human consumption or diagnostic purposes.<\/span>
\nRelated categories and reagents:<\/strong> In the context of this area of \u200b\u200bresearch, it is also worth comparing CJC without DAC<\/a> and GHRP-6<\/a>.<\/p>\n

Ipamorelin vs GHRP-6.<\/strong> Both are agonists of the ghrelin receptor GHS-R1a, but ipamorelin is a pentapeptide (711.85 g\/mol), whereas GHRP-6 is a hexapeptide (873.01 g\/mol). Ipamorelin’s research identity is based on selectivity: in vitro studies did not report increases in cortisol and prolactin to the extent described for older GHRPs. This is why the literature sometimes selects it as a tool for isolating GHS-R1a signaling.<\/p>\n

Ipamorelin vs CJC-1295 without DAC.<\/strong> Different receptors: CJC-1295 (3,367.9 g\/mol) is a GHRH analogue described in relation to GHRH-R. Comparisons of the two in the literature result from their representing two independent entry points into the growth hormone axis, not from molecular similarity.<\/p>\n

Introduction and research framework<\/strong><\/h2>\n

Ipamorelin is a synthetic pentapeptide belonging to the third generation of growth hormone secretagogues (GHS). This peptide was developed by Novo Nordisk in the 1990s as a highly selective agonist of the GHS-R1a receptor (ghrelin receptor), distinguished by minimal impact on other hormonal systems.<\/p>\n

Compared to previous GH secretagogues, such as GHRP-6 or GHRP-2, Ipamorelin is characterized by greater receptor selectivity. This property makes it a valuable tool in the study of specific ghrelin receptor signaling mechanisms, without interfering effects on other hormonal pathways.<\/p>\n

General characteristics of the Ipamorelin compound<\/strong><\/h2>\n

Ipamorelin is a pentapeptide with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH2, containing unnatural amino acids that give it increased stability and selectivity. It is one of the newest peptides in the GHS series, designed to maximize selectivity towards the GHS-R1a receptor.<\/p>\n

Key features of Ipamorelinau as a research tool:<\/p>\n

    \n
  • High selectivity towards GHS-R1a<\/li>\n
  • No effect on other pituitary hormones (in in vitro models)<\/li>\n
  • Presence of unnatural amino acids<\/li>\n
  • Good metabolic stability<\/li>\n<\/ul>\n

    The One Peptides Ipamorelin 2 mg material is supplied in the form of a high-purity lyophilized powder, intended for use in biochemical and pharmacological research.<\/p>\n

    \"Ipamorelin<\/p>\n

    What is Ipamorelin?<\/strong><\/h2>\n

    Ipamorelin is a synthetic peptide belonging to the class of growth hormone secretagogues (GHS), designed as a highly selective agonist of the GHS-R1a receptor. Unlike previous GHRPs, Ipamorelin does not show significant affinity for opioid receptors or influence the secretion of cortisol or prolactin in in vitro tests.<\/p>\n

    Nomenclature and Synonyms<\/strong><\/h3>\n\n\n\n\n\n\n\n
    Name<\/th>\nDescription<\/th>\n<\/tr>\n<\/thead>\n
    Ipamorelin<\/td>\nCommon name<\/td>\n<\/tr>\n
    NNC 26-0161<\/td>\nCode designation Novo Nordisk<\/td>\n<\/tr>\n
    Ipamorelin acetate<\/td>\nAcetate salt form<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Classification<\/strong><\/h3>\n\n\n\n\n\n\n\n\n\n
    Characteristic<\/th>\nDescription<\/th>\n<\/tr>\n<\/thead>\n
    Class<\/td>\nGrowth hormone secretagogue (GHS)<\/td>\n<\/tr>\n
    Generation<\/td>\n3rd generation GHRP<\/td>\n<\/tr>\n
    Target receptor<\/td>\nGHS-R1a (ghrelin receptor)<\/td>\n<\/tr>\n
    Structure<\/td>\nSynthetic pentapeptide<\/td>\n<\/tr>\n
    Selectivity<\/td>\nHigh for GHS-R1a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    GHS Generation Comparison<\/strong><\/h3>\n\n\n\n\n\n\n\n
    Generation<\/th>\nExamples<\/th>\nCharacteristics<\/th>\n<\/tr>\n<\/thead>\n
    AND<\/td>\nGHRP-6<\/td>\nLow selectivity<\/td>\n<\/tr>\n
    II<\/td>\nGHRP-2, Hexarelin<\/td>\nAverage selectivity<\/td>\n<\/tr>\n
    III<\/td>\nIpamorelin<\/td>\nHigh selectivity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Structure and physicochemical properties<\/strong><\/h2>\n

    Amino Acid Sequence<\/strong><\/h3>\n

    Ipamorelin consists of 5 amino acids, including two unnatural ones:<\/p>\n

    H-Aib-His-D-2Nal-D-Phe-Lys-NH2<\/strong><\/p>\n

    Where:<\/p>\n

      \n
    • Aib \u2013 2-aminoisobutyric acid (\u03b1-aminoisobutyric acid)<\/li>\n
    • His \u2013 L-histidine<\/li>\n
    • D-2Nal \u2013 D-2-naphthylalanine<\/li>\n
    • D-Phe \u2013 D-phenylalanine<\/li>\n
    • Lys \u2013 L-lysine (C-terminus amidated)<\/li>\n<\/ul>\n

      Characteristics of Amino Acids<\/strong><\/h3>\n
        \n
      • Position 1 (Aib)<\/strong> \u2013 unnatural amino acid, stabilizes conformation<\/li>\n
      • Position 2 (His)<\/strong> \u2013 L-histidine, a basic amino acid<\/li>\n
      • Position 3 (D-2Nal)<\/strong> \u2013 D-2-naphthylalanine, a large aromatic amino acid<\/li>\n
      • Position 4 (D-Phe)<\/strong> \u2013 D-phenylalanine, D configuration<\/li>\n
      • Position 5 (Lys)<\/strong> \u2013 L-lysine, C-terminus amidated<\/li>\n<\/ul>\n

        Physicochemical properties<\/strong><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n
        Parameter<\/th>\nValue<\/th>\n<\/tr>\n<\/thead>\n
        Summary formula<\/td>\nC38H49N9O5<\/td>\n<\/tr>\n
        Molar mass<\/td>\n711.85 g\/mol<\/td>\n<\/tr>\n
        CAS number<\/td>\n170851-70-4<\/td>\n<\/tr>\n
        Number of amino acids<\/td>\n5<\/td>\n<\/tr>\n
        C-end<\/td>\nAmidated (-NH2)<\/td>\n<\/tr>\n
        Unnatural amino acids<\/td>\n2 (Aib, D-2Nal)<\/td>\n<\/tr>\n
        Solubility<\/td>\nSoluble in water<\/td>\n<\/tr>\n
        Form<\/td>\nFreeze-dried powder (white)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Comparison with Other GHS<\/strong><\/h3>\n\n\n\n\n\n\n\n\n
        Peptide<\/th>\nSequence<\/th>\nMass (g\/mol)<\/th>\nSelectivity<\/th>\n<\/tr>\n<\/thead>\n
        Ipamorelin<\/td>\nAib-His-D-2Nal-D-Phe-Lys<\/td>\n711,85<\/td>\nHigh<\/td>\n<\/tr>\n
        GHRP-2<\/td>\nD-Ala-D-2Nal-Ala-Trp-D-Phe-Lys<\/td>\n817,97<\/td>\nMean<\/td>\n<\/tr>\n
        GHRP-6<\/td>\nHis-D-Trp-Ala-Trp-D-Phe-Lys<\/td>\n873,01<\/td>\nLow<\/td>\n<\/tr>\n
        Hexarelin<\/td>\nHis-D-2MeTrp-Ala-Trp-D-Phe-Lys<\/td>\n887,04<\/td>\nMean<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Purity, identification and quality control<\/strong><\/h2>\n

        Product Specification ONE Ipamorelin 2 mg<\/strong><\/h3>\n

        Quality parameters:<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
        Test<\/th>\nMethod<\/th>\nSpecification<\/th>\n<\/tr>\n<\/thead>\n
        Cleanliness<\/td>\nHPLC<\/td>\n\u226598%<\/td>\n<\/tr>\n
        Identification<\/td>\nMS<\/td>\n711.85 \u00b1 0.5 Da<\/td>\n<\/tr>\n
        Water content<\/td>\nKarl Fischer<\/td>\n\u22648%<\/td>\n<\/tr>\n
        Acetate content<\/td>\nTitration<\/td>\n\u226412%<\/td>\n<\/tr>\n
        Appearance<\/td>\nVisual<\/td>\nWhite lyophilisate<\/td>\n<\/tr>\n
        Solubility<\/td>\nTest<\/td>\nClear in water<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Storage and laboratory handling<\/strong><\/h2>\n

        Ipamorelin Storage Conditions<\/strong><\/h3>\n

        Freeze-dried form:<\/strong>
        \n– Temperature: -20\u00b0C (optimal)
        \n– Permissible: 2-8\u00b0C (up to 1 month)
        \n– Protect from light and moisture
        \n– Shelf life: 24 months at -20\u00b0C<\/p>\n

        After reconstitution:<\/strong>
        \n– Solvent: sterile water or bacteriostatic water
        \n– Storage: 2-8\u00b0C
        \n– Use within 14-21 days
        \n– Possibility to freeze aliquots<\/p>\n

        Reconstitution Instructions<\/strong><\/h3>\n
          \n
        1. Equalize the temperature of the vial (15-20 min)<\/li>\n
        2. Add the solvent slowly along the wall<\/li>\n
        3. Recommended concentration: 1-2 mg\/ml<\/li>\n
        4. Rotate gently – do not vortex<\/li>\n
        5. The solution should be clear<\/li>\n
        6. Store in the refrigerator<\/li>\n<\/ol>\n

          Ipamorelin stability<\/strong><\/h3>\n

          Ipamorelin shows good stability due to:<\/p>\n

            \n
          • Presence of Aib (increases resistance to proteases)<\/li>\n
          • D-amino acids (D-2Nal, D-Phe)<\/li>\n
          • C-terminal amidation<\/li>\n<\/ul>\n

            Mechanism of action at the molecular level<\/strong><\/h2>\n

            GHS-R1a receptor<\/strong><\/h3>\n

            Ipamorelin is being investigated as a selective GHS-R1a receptor agonist. In vitro tests analyze:<\/p>\n

            Binding characteristics:<\/strong>
            \n– High affinity for GHS-R1a
            \n– Low activity against other GPCRs
            \n– Comparison with ghrelin and other GHSs<\/p>\n

            Selectivity:<\/strong><\/p>\n\n\n\n\n\n\n\n\n
            Receptor\/Parameter<\/th>\nIpamorelin<\/th>\nGHRP-6<\/th>\n<\/tr>\n<\/thead>\n
            GHS-R1a<\/td>\n+++<\/td>\n+++<\/td>\n<\/tr>\n
            Opioid receptors<\/td>\n\u00b1<\/td>\n++<\/td>\n<\/tr>\n
            ACTH (in vitro)<\/td>\n\u2013<\/td>\n+<\/td>\n<\/tr>\n
            Prolactin (in vitro)<\/td>\n\u2013<\/td>\n+<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            Intracellular Signaling<\/strong><\/h3>\n

            In studies on cell cultures expressing GHS-R1a:<\/p>\n

              \n
            • Activation of the Gq\/11 pathway<\/li>\n
            • IP3 production<\/li>\n
            • Intracellular Ca2+ release<\/li>\n
            • PKC activation<\/li>\n<\/ul>\n

              Comparative Research<\/strong><\/h3>\n

              Ipamorelin is often compared with:<\/p>\n

                \n
              • GHRP-2 and GHRP-6<\/li>\n
              • Hexarelin<\/li>\n
              • Ghrelin (endogenous ligand)<\/li>\n
              • MK-677 (ghrelin mimetic, non-peptide)<\/li>\n<\/ul>\n

                Ipamorelin – Applications in Scientific Research<\/strong><\/h2>\n

                Receptor Research<\/strong><\/h3>\n
                  \n
                • GHS-R1a characteristics without off-target effects<\/li>\n
                • Selective activation of the signaling pathway<\/li>\n
                • Comparison with non-selective agonists<\/li>\n
                • Structure-activity studies<\/li>\n<\/ul>\n

                  Pharmacological Research<\/strong><\/h3>\n
                    \n
                  • GHS-R1a selective activation model<\/li>\n
                  • Comparison of activity profiles of different GHSs<\/li>\n
                  • Dose-response studies<\/li>\n
                  • Kinetics of receptor-ligand binding<\/li>\n<\/ul>\n

                    Signaling Research<\/strong><\/h3>\n
                      \n
                    • Downstream pathways selectively activated<\/li>\n
                    • Comparison with non-selective agonists<\/li>\n
                    • Mechanisms of receptor desensitization<\/li>\n
                    • GHS-R1a internalization<\/li>\n<\/ul>\n

                      Peptide Biochemistry<\/strong><\/h3>\n
                        \n
                      • Effect of Aib on conformation and stability<\/li>\n
                      • The importance of D-amino acids<\/li>\n
                      • Selectivity optimization by structural modifications<\/li>\n<\/ul>\n

                        Reservations<\/strong><\/h3>\n

                        IMPORTANT:<\/strong> The product is intended for in vitro testing only. Not intended for:
                        \n– Use in humans or animals
                        \n– Diagnostic or therapeutic purposes
                        \n– Application in sports<\/p>\n

                        Summary<\/strong><\/h2>\n

                        Ipamorelin is a synthetic pentapeptide of the third generation of growth hormone secretagogues, characterized by high selectivity towards the GHS-R1a receptor. The presence of unnatural amino acids (Aib, D-2Nal) ensures good stability and unique pharmacological properties, making it a valuable tool in research on the selective activation of the ghrelin receptor.<\/p>\n

                        Material One Peptides Ipamorelin 2 mg offers:<\/p>\n

                          \n
                        • High purity \u226598% HPLC<\/li>\n
                        • Full spectrometric characterization<\/li>\n
                        • Stable freeze-dried form<\/li>\n
                        • Certificate of analysis for each batch<\/li>\n<\/ul>\n

                          Ipamorelin – Scientific FAQ<\/strong><\/h2>\n

                          1. What is Ipamorelin and what is its structure?<\/strong><\/h3>\n

                          Ipamorelin is a synthetic pentapeptide with the sequence Aib-His-D-2Nal-D-Phe-Lys-NH2, containing two unnatural amino acids (Aib and D-2-naphthylalanine). The molar mass is 711.85 g\/mol and the CAS number is 170851-70-4. It is a third-generation selective GHS-R1a receptor (ghrelin receptor) agonist.<\/p>\n

                          2. How is Ipamorelin different from other GH secretagogues?<\/strong><\/h3>\n

                          Ipamorelin is characterized by high selectivity towards the GHS-R1a receptor. Unlike GHRP-6 or GHRP-2, in vitro studies show no significant activity towards opioid receptors or influence the secretion of cortisol and prolactin. This makes it a useful tool for examining the specific effects of GHS-R1a activation.<\/p>\n

                          3. How to store Ipamorelin?<\/strong><\/h3>\n

                          In freeze-dried form, Ipamorelin is stored at -20\u00b0C, protected from light and moisture. Due to the presence of Aib and D-amino acids, it is relatively stable. After reconstitution in sterile water, the solution is stored at 2-8\u00b0C for up to 14-21 days or frozen in small portions.<\/p>\n

                          4. What does the abbreviation “Aib” mean in the sequence?<\/strong><\/h3>\n

                          Aib is 2-aminoisobutyric acid (\u03b1-aminoisobutyric acid) – an unnatural amino acid with two methyl groups on the \u03b1 carbon. Its presence in the N-terminal position increases the stability of the peptide towards aminopeptidases and influences the conformation of the peptide chain, promoting a helical structure.<\/p>\n

                          5. What tests is Ipamorelin used for?<\/strong><\/h3>\n

                          Ipamorelin is used in in vitro studies as a tool to selectively activate the GHS-R1a receptor. Applications include: receptor studies, signaling pathway analyses, comparisons with other GH secretagogues, and structure-activity studies. It is not intended for use on humans or animals.<\/p>\n

                          The most important research conclusions<\/strong><\/h2>\n

                          The most important features of the ONE Ipamorelin 2 mg product:<\/strong><\/p>\n

                            \n
                          • Type<\/strong> \u2013 3rd generation GH secretagogue<\/li>\n
                          • Sequence<\/strong> \u2013 Aib-His-D-2Nal-D-Phe-Lys-NH2<\/li>\n
                          • Molar mass<\/strong> \u2013 711.85 g\/mol<\/li>\n
                          • CAS number<\/strong> \u2013 170851-70-4<\/li>\n
                          • Receptor<\/strong> \u2013 GHS-R1a (high selectivity)<\/li>\n
                          • Cleanliness<\/strong> \u2013 minimum 98% HPLC<\/li>\n
                          • Form<\/strong> \u2013 lyophilisate (white powder)<\/li>\n
                          • Unnatural amino acids<\/strong> \u2013 Aib, D-2Nal<\/li>\n
                          • Destiny<\/strong> \u2013 only in vitro tests<\/li>\n<\/ul>\n
                            \n

                            Bibliography<\/h3>\n
                              \n
                            1. Raun K, et al. (1998)<\/strong> “Ipamorelin, the first selective growth hormone secretagogue” – European Journal of Endocrinology, 139(5):552-561.
                              \nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/9849822\/<\/li>\n
                            2. Anderson LL, et al. (2001)<\/strong> “Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats” – Growth Hormone & IGF Research, 11(1):14-18.
                              \nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/11437469\/<\/li>\n
                            3. Hansen BS, et al. (1999)<\/strong> “The growth hormone secretagogue receptor: pharmacological and physiological aspects” – Growth Hormone & IGF Research, 9 Suppl A:33-39.
                              \nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/10429878\/<\/li>\n<\/ol>\n<\/section>\n
                              \n

                              Chemical data source<\/h3>\n
                                \n
                              • PubChem. Ipamorelin, CID 9831659<\/cite><\/a>.<\/li>\n<\/ul>\n<\/section>\n

                                Literature context:<\/strong> see the overview research on Ipamorelin<\/a> in the context of laboratory research and RUO framing.<\/p>\n

                                Parent category:<\/strong> Peptides for Regeneration<\/a> organize RUO reagents associated with recovery-related research contexts.<\/p>\n