{"id":2010,"date":"2026-06-15T22:35:32","date_gmt":"2026-06-15T22:35:32","guid":{"rendered":"https:\/\/one-peptides.com\/product\/somatex-gh-pen\/"},"modified":"2026-10-11T11:55:41","modified_gmt":"2026-10-11T11:55:41","slug":"somatex-gh-pen","status":"publish","type":"product","link":"https:\/\/one-peptides.com\/de\/produkt\/somatex-gh-pen\/","title":{"rendered":"Somatex GH pen"},"content":{"rendered":"

Regulatory framework + WADA<\/strong><\/em><\/p>\n

Somatex PEN 60 IU is a chemical reagent intended exclusively for laboratory research (Research Use Only)<\/strong> in pen format. The active substance \u2014 somatropin (recombinant human growth hormone, rhGH)<\/strong> \u2014 is also present on the market as a registered medicinal product under the trade names of numerous pharmaceutical manufacturers. These two instances are two distinct regulatory frameworks<\/strong> \u2014 the RUO reagent is not a medicine, is not intended for human use, and is not subject to pharmaceutical regulation. Somatropin is on the WADA Prohibited List (category S2 \u2014 peptide hormones and growth factors)<\/strong> \u2014 athletes subject to anti-doping control may not use it at any point during the year.<\/em><\/p>\n

Growth hormone<\/strong> is one of the best-characterized signaling proteins in endocrinology \u2014 from its isolation in the 1950s to recombinant production by genetic engineering, which replaced extraction from human cadaver pituitaries. Somatropin is a synthetic, recombinant version of human growth hormone with a sequence identical to the endogenous protein. In the research reagent market it is available in pen format \u2014 a pre-dissolved cartridge enabling precise withdrawal of solution in laboratory protocols studying the GH-IGF1 axis. Somatex PEN belongs to the 191 amino acid sequence<\/a> category \u2014 authentic, full-length somatropin.<\/p>\n

This description is educational in nature and describes the scientific literature on somatropin in a research context. The Somatex PEN product functions exclusively as a chemical reagent for laboratory research (Research Use Only). It is not a medicinal product, dietary supplement, or food product.<\/em><\/p>\n

What is somatropin \u2014 structure and class<\/h2>\n

Somatropin is a recombinant human growth hormone (rhGH)<\/strong> \u2014 a polypeptide of 191 amino acids<\/strong> with a molecular weight of approximately 22,124 Da (22 kDa)<\/strong>, containing two intramolecular disulfide bridges. The somatropin sequence is identical to the endogenous growth hormone<\/strong> produced by the somatotroph cells of the anterior pituitary lobe.<\/p>\n

Recombinant production of somatropin \u2014 in bacterial cells (Escherichia coli) or mammalian cells carrying an introduced human GH gene \u2014 replaced the historical method of obtaining the hormone from human cadaver pituitaries, which carried a risk of transmitting prion diseases. Modern somatropin is a product of genetic engineering with high purity and reproducibility.<\/p>\n

Chemical characteristics<\/h3>\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n
Name<\/td>\nSomatropin (recombinant human growth hormone, rhGH)<\/td>\n<\/tr>\n
Number of amino acids<\/td>\n191<\/td>\n<\/tr>\n
Molecular weight<\/td>\n~22,124 Da (22 kDa)<\/td>\n<\/tr>\n
Disulfide bridges<\/td>\n2 intramolecular<\/td>\n<\/tr>\n
Class<\/td>\nPeptide hormone \/ growth factor<\/td>\n<\/tr>\n
Sequence<\/td>\nIdentical to endogenous human GH<\/td>\n<\/tr>\n
Content per pen<\/td>\n60 IU (~20 mg, per WHO conversion 1 mg = 3 IU)<\/td>\n<\/tr>\n
Physical form<\/td>\nPre-dissolved solution in pen cartridge<\/td>\n<\/tr>\n
HPLC purity<\/td>\n\u226598%<\/td>\n<\/tr>\n
Identity confirmation<\/td>\nMass spectrometry (MS)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Mechanism of action in research<\/h2>\n

Somatropin binds to the growth hormone receptor (GHR)<\/strong> \u2014 a membrane receptor from the cytokine receptor family. Binding of one hormone molecule to two receptor subunits leads to receptor dimerization and activation of an intracellular signaling cascade:<\/p>\n