{"id":1012,"date":"2024-11-23T08:19:01","date_gmt":"2024-11-23T08:19:01","guid":{"rendered":"https:\/\/one-peptides.com\/product\/melanotan-ii-10mg\/"},"modified":"2026-09-29T17:05:18","modified_gmt":"2026-09-29T17:05:18","slug":"melanotan-ii-10mg","status":"publish","type":"product","link":"https:\/\/one-peptides.com\/de\/produkt\/melanotan-ii-10mg\/","title":{"rendered":"MELANOTAN II 10 mg"},"content":{"rendered":"<h2><strong>One Peptides Melanotan II 10 mg &#8211; chemical reagent for laboratory tests<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">Melanotan &#8211; Research Use Only (RUO). Chemical reagent intended only for laboratory tests. It is not intended for human consumption or diagnostic purposes.<\/span><br \/>\n<strong>Related categories and reagents:<\/strong> In the context of this area of \u200b\u200bresearch, it is also worth comparing <a href=\"https:\/\/one-peptides.com\/product\/ghk-cu-50mg\/\">GHK-Cu copper peptide<\/a> and <a href=\"https:\/\/one-peptides.com\/product\/epithalon-10mg\/\">Epithalon anti-aging peptide<\/a>.<\/p>\n<p><strong>Melanotan II vs GHK-Cu and Epithalon.<\/strong> They are sometimes grouped as &#8220;short peptides,&#8221; but the mechanisms described in the literature are distinct. Melanotan II (1,024.18 g\/mol) is a cyclic heptapeptide\u2014an \u03b1-MSH analogue described as a nonselective agonist of the melanocortin receptors MC1R, MC3R, MC4R and MC5R. GHK-Cu (approximately 403 g\/mol with Cu\u00b2\u207a) is not a ligand of melanocortin receptors; its research identity is a tripeptide-copper complex. Epithalon (390.35 g\/mol) is a tetrapeptide without a metal ion and without described affinity for MC receptors. Only the chemical class is shared, not the molecular target, and the mass difference (1,024 versus 390\u2013403 g\/mol) reflects two different orders of molecular size.<\/p>\n<h2><strong>Introduction and research framework<\/strong><\/h2>\n<p>Melanotan II (MT-II) is a synthetic cyclic heptapeptide that is an analogue of the naturally occurring hormone \u03b1-melanotropin (\u03b1-MSH \u2013 \u03b1-Melanocyte Stimulating Hormone). The peptide was developed at the University of Arizona in the 1980s by a team led by Dr. Victor Hruby as a tool for research on melanocortin receptors.<\/p>\n<p>Melanotan II is characterized by a cyclic structure, which gives it increased metabolic stability compared to linear \u03b1-MSH. As a non-selective agonist of melanocortin receptors (MCR), this peptide is used in scientific research on the signaling pathways and functions of individual MC1R-MC5R subtypes.<\/p>\n<h2><strong>General characteristics of the melanotan II compound<\/strong><\/h2>\n<p>Melanotan II is a cyclic peptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, designed as a stable analogue of \u03b1-MSH. Cyclization through the lactone bond between Asp and Lys and the presence of D-phenylalanine increase resistance to enzymatic degradation.<\/p>\n<p>In the context of scientific research, Melanotan II serves as:<\/p>\n<ul>\n<li>Non-selective agonist of melanocortin receptors<\/li>\n<li>MC1R-MC5R pathway research tool<\/li>\n<li>Structural model for the design of selective ligands<\/li>\n<li>The standard in melanocortin research<\/li>\n<\/ul>\n<p>The One Peptides Melanotan II 10 mg material is supplied in the form of a high-purity freeze-dried powder intended for use in biochemical and pharmacological research.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-1151 size-large\" src=\"https:\/\/one-peptides.com\/wp-content\/uploads\/2025\/07\/Melanotan-II-Camera-e1751210988820-1024x722.png\" alt=\"melanotan II odczynnik chemiczny\" width=\"800\" height=\"564\" \/><\/p>\n<h2><strong>What is Melanotan II?<\/strong><\/h2>\n<p>MT II is a synthetic analogue of \u03b1-MSH, designed to increase stability and potency compared to the natural hormone. \u03b1-MSH is a product of post-translational processing of proopiomelanocortin (POMC) and acts through melanocortin receptors (MCR).<\/p>\n<h3><strong>History of Development<\/strong><\/h3>\n<table>\n<thead>\n<tr>\n<th>Year<\/th>\n<th>Event<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>1980s<\/td>\n<td>Melanotan II Synthesis (University of Arizona)<\/td>\n<\/tr>\n<tr>\n<td>1991<\/td>\n<td>Publication of structure and properties<\/td>\n<\/tr>\n<tr>\n<td>1990s<\/td>\n<td>Studies on melanocortin receptors<\/td>\n<\/tr>\n<tr>\n<td>2000s+<\/td>\n<td>Intensive research on molecular mechanisms<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><strong>Comparison with \u03b1-MSH<\/strong><\/h3>\n<table>\n<thead>\n<tr>\n<th>Characteristic<\/th>\n<th>\u03b1-MSH<\/th>\n<th>Melanotan II<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Structure<\/td>\n<td>Linear (13 AA)<\/td>\n<td>Cyclic (7 AA)<\/td>\n<\/tr>\n<tr>\n<td>Sequence<\/td>\n<td>Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2<\/td>\n<td>Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2<\/td>\n<\/tr>\n<tr>\n<td>Stability<\/td>\n<td>Low<\/td>\n<td>High<\/td>\n<\/tr>\n<tr>\n<td>MCR selectivity<\/td>\n<td>Low<\/td>\n<td>Low<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><strong>Melanocortin family<\/strong><\/h3>\n<table>\n<thead>\n<tr>\n<th>Peptide<\/th>\n<th>Source<\/th>\n<th>Receptors<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u03b1-MSH<\/td>\n<td>POMC<\/td>\n<td>MC1R, MC3R, MC4R, MC5R<\/td>\n<\/tr>\n<tr>\n<td>\u03b2-MSH<\/td>\n<td>POMC<\/td>\n<td>MC1R, MC3R, MC4R<\/td>\n<\/tr>\n<tr>\n<td>\u03b3-MSH<\/td>\n<td>POMC<\/td>\n<td>MC3R<\/td>\n<\/tr>\n<tr>\n<td>ACTH<\/td>\n<td>POMC<\/td>\n<td>MC2R (mainly)<\/td>\n<\/tr>\n<tr>\n<td>Melanotan II<\/td>\n<td>Synthetic<\/td>\n<td>MC1R-MC5R<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><strong>Structure and physicochemical properties<\/strong><\/h2>\n<h3><strong>Sequence and Structure<\/strong><\/h3>\n<p>Melanotan II is a cyclic heptapeptide:<\/p>\n<p><strong>Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2<\/strong><\/p>\n<p>Where:<\/p>\n<ul>\n<li>Ac \u2013 acetyl group at the N-terminus<\/li>\n<li>Nle \u2013 norleucine (replaces Met with \u03b1-MSH)<\/li>\n<li>cyclo[Asp&#8230;Lys] \u2013 cyclization by amide bond between side chains<\/li>\n<li>D-Phe \u2013 D-phenylalanine (increases stability)<\/li>\n<li>NH2 \u2013 C-terminal amidation<\/li>\n<\/ul>\n<h3><strong>Characteristics of Amino Acids<\/strong><\/h3>\n<ul>\n<li><strong>Position 1 (Nle)<\/strong> \u2013 norleucine, replaces methionine (avoids oxidation)<\/li>\n<li><strong>Position 2 (Asp)<\/strong> \u2013 aspartic acid, participates in cyclization<\/li>\n<li><strong>Position 3 (His)<\/strong> \u2013 histidine, part of the pharmacophore core<\/li>\n<li><strong>Position 4 (D-Phe)<\/strong> \u2013 D-phenylalanine, part of the core (D configuration!)<\/li>\n<li><strong>Position 5 (Arg)<\/strong> \u2013 arginine, part of the pharmacophore core<\/li>\n<li><strong>Position 6 (Trp)<\/strong> \u2013 tryptophan, part of the pharmacophore core<\/li>\n<li><strong>Position 7 (Lys)<\/strong> \u2013 lysine, participates in cyclization<\/li>\n<\/ul>\n<h3><strong>Pharmacophore Core<\/strong><\/h3>\n<p>The His-Phe-Arg-Trp sequence constitutes the core pharmacophore of melanocortins, conserved in Melanotan II (as His-D-Phe-Arg-Trp).<\/p>\n<h3><strong>Physicochemical properties<\/strong><\/h3>\n<table>\n<thead>\n<tr>\n<th>Parameter<\/th>\n<th>Value<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Summary formula<\/td>\n<td>C50H69N15O9<\/td>\n<\/tr>\n<tr>\n<td>Molar mass<\/td>\n<td>1024.18 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>CAS number<\/td>\n<td>121062-08-6<\/td>\n<\/tr>\n<tr>\n<td>Number of amino acids<\/td>\n<td>7<\/td>\n<\/tr>\n<tr>\n<td>Structure<\/td>\n<td>Cyclic (lactone)<\/td>\n<\/tr>\n<tr>\n<td>N-end<\/td>\n<td>Acetylated<\/td>\n<\/tr>\n<tr>\n<td>C-end<\/td>\n<td>Amidated<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>Soluble in water<\/td>\n<\/tr>\n<tr>\n<td>Form<\/td>\n<td>Freeze-dried powder (white)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><strong>Comparison with Melanotan I<\/strong><\/h3>\n<table>\n<thead>\n<tr>\n<th>Characteristic<\/th>\n<th>Melanotan I (Afamelanotide)<\/th>\n<th>Melanotan II<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Structure<\/td>\n<td>Linear<\/td>\n<td>Cyclic<\/td>\n<\/tr>\n<tr>\n<td>Length<\/td>\n<td>13 A.A<\/td>\n<td>7 A.A<\/td>\n<\/tr>\n<tr>\n<td>Molar mass<\/td>\n<td>~1646 Da<\/td>\n<td>~1024 Da<\/td>\n<\/tr>\n<tr>\n<td>Primary receptor<\/td>\n<td>MC1R<\/td>\n<td>MC1R-MC5R<\/td>\n<\/tr>\n<tr>\n<td>Selectivity<\/td>\n<td>Higher for MC1R<\/td>\n<td>Non-selective<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><strong>Purity, identification and quality control<\/strong><\/h2>\n<h3><strong>Product Specification ONE Melanotan II 10 mg<\/strong><\/h3>\n<p><strong>Quality parameters:<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th>Test<\/th>\n<th>Method<\/th>\n<th>Specification<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Cleanliness<\/td>\n<td>HPLC<\/td>\n<td>\u226598%<\/td>\n<\/tr>\n<tr>\n<td>Identification<\/td>\n<td>MS<\/td>\n<td>1024.18 \u00b1 0.5 Da<\/td>\n<\/tr>\n<tr>\n<td>Water content<\/td>\n<td>Karl Fischer<\/td>\n<td>\u22648%<\/td>\n<\/tr>\n<tr>\n<td>Acetate content<\/td>\n<td>Titration<\/td>\n<td>\u226412%<\/td>\n<\/tr>\n<tr>\n<td>Appearance<\/td>\n<td>Visual<\/td>\n<td>White lyophilisate<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>Test<\/td>\n<td>Clear in water<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><strong>Storage and laboratory handling<\/strong><\/h2>\n<h3><strong>Storage Conditions<\/strong><\/h3>\n<p><strong>Freeze-dried form:<\/strong><br \/>\n&#8211; Temperature: -20\u00b0C (optimal)<br \/>\n&#8211; Permissible: 2-8\u00b0C (up to 1 month)<br \/>\n&#8211; Protect from light (tryptophan)<br \/>\n&#8211; Protect against moisture<br \/>\n&#8211; Shelf life: 24 months at -20\u00b0C<\/p>\n<p><strong>After reconstitution:<\/strong><br \/>\n&#8211; Solvent: sterile water or bacteriostatic water<br \/>\n&#8211; Storage: 2-8\u00b0C in the dark<br \/>\n&#8211; Use within 14-21 days<br \/>\n&#8211; Freezing aliquots recommended<\/p>\n<h3><strong>Reconstitution Instructions<\/strong><\/h3>\n<ol>\n<li>Equalize the temperature of the vial (15-20 min)<\/li>\n<li>Add sterile water slowly along the side<\/li>\n<li>Recommended concentration: 1-2 mg\/ml<\/li>\n<li>Mix gently by turning<\/li>\n<li>The solution should be clear<\/li>\n<li>Protect from light<\/li>\n<\/ol>\n<h3><strong>Stability<\/strong><\/h3>\n<p>The cyclic structure of Melanotan II provides:<\/p>\n<ul>\n<li>Increased resistance to proteases<\/li>\n<li>Longer stability in solution than \u03b1-MSH<\/li>\n<li>Oxidation protection (Nle instead of Met)<\/li>\n<\/ul>\n<h2><strong>Mechanism of action at the molecular level<\/strong><\/h2>\n<h3><strong>Melanocortin receptors<\/strong><\/h3>\n<p>Melanotan II is a non-selective agonist of melanocortin receptors (MCR), Gs-protein coupled GPCRs:<\/p>\n<p><strong>Receptor affinity (in vitro):<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th>Receptor<\/th>\n<th>Location<\/th>\n<th>MT-II<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>MC1R<\/td>\n<td>Melanocytes, immune cells<\/td>\n<td>+++<\/td>\n<\/tr>\n<tr>\n<td>MC2R<\/td>\n<td>Adrenal cortex<\/td>\n<td>+<\/td>\n<\/tr>\n<tr>\n<td>MC3R<\/td>\n<td>CNS, adipose tissue<\/td>\n<td>+++<\/td>\n<\/tr>\n<tr>\n<td>MC4R<\/td>\n<td>CNS (hypothalamus)<\/td>\n<td>+++<\/td>\n<\/tr>\n<tr>\n<td>MC5R<\/td>\n<td>Exocrine glands<\/td>\n<td>++<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><strong>Intracellular Signaling<\/strong><\/h3>\n<p>In cell culture studies:<\/p>\n<ul>\n<li>Activation of adenylase cyclase<\/li>\n<li>Increase in cAMP levels<\/li>\n<li>PKA activation<\/li>\n<li>CREB phosphorylation<\/li>\n<\/ul>\n<h3><strong>Comparative Research<\/strong><\/h3>\n<p>Melanotan II is compared with:<\/p>\n<ul>\n<li>\u03b1-MSH (endogenous ligand)<\/li>\n<li>Melanotan I (selective MC1R)<\/li>\n<li>Bremelanotide (PT-141, MT-II analogue)<\/li>\n<li>Setmelanotide (selective MC4R)<\/li>\n<\/ul>\n<h3><strong>Pharmacophore Core<\/strong><\/h3>\n<p>The His-D-Phe-Arg-Trp sequence is essential for activity. Structure-activity studies showed:<\/p>\n<ul>\n<li>His crucial for binding<\/li>\n<li>D-Phe increases stability and potency<\/li>\n<li>Arg and Trp necessary for activation<\/li>\n<\/ul>\n<h2><strong>Applications in Scientific Research<\/strong><\/h2>\n<h3><strong>Receptor Research<\/strong><\/h3>\n<ul>\n<li>Characterization of MC1R-MC5R receptors<\/li>\n<li>Binding and activation studies<\/li>\n<li>Selectivity and specificity<\/li>\n<li>Desensitization and internalization<\/li>\n<\/ul>\n<h3><strong>Signaling Research<\/strong><\/h3>\n<ul>\n<li>cAMP\/PKA\/CREB pathways<\/li>\n<li>Crosstalk with other GPCRs<\/li>\n<li>Mechanisms of regulation of gene expression<\/li>\n<li>Transcription modulation<\/li>\n<\/ul>\n<h3><strong>Structure-Activity Research<\/strong><\/h3>\n<ul>\n<li>Optimization of receptor selectivity<\/li>\n<li>The role of cyclization in stability<\/li>\n<li>The importance of individual amino acids<\/li>\n<li>Designing new analogues<\/li>\n<\/ul>\n<h3><strong>Melanocyte Biology (In Vitro)<\/strong><\/h3>\n<ul>\n<li>Mechanisms of melanogenesis<\/li>\n<li>Tyrosinase regulation<\/li>\n<li>Signaling pathways in melanocytes<\/li>\n<li>Interactions with other factors<\/li>\n<\/ul>\n<h3><strong>Neurobiology<\/strong><\/h3>\n<ul>\n<li>MCR expression in the CNS<\/li>\n<li>MC3R and MC4R functions<\/li>\n<li>Research models for MC4R<\/li>\n<\/ul>\n<h3><strong>Reservations<\/strong><\/h3>\n<p><strong>IMPORTANT:<\/strong> The product is intended for in vitro testing only. Not intended for:<br \/>\n&#8211; Use in humans or animals<br \/>\n&#8211; Cosmetic or therapeutic purposes<br \/>\n&#8211; Any clinical use<\/p>\n<h2><strong>Summary<\/strong><\/h2>\n<p>Melanotan II is a cyclic synthetic analog of \u03b1-MSH, characterized by non-selective agonism towards MC1R-MC5R melanocortin receptors. Its stable cyclic structure and well-understood pharmacological properties make it a valuable tool in research on the melanocortin system.<\/p>\n<p>Material One Peptides Melanotan II 10 mg offers:<\/p>\n<ul>\n<li>High purity \u226598% HPLC<\/li>\n<li>Confirmed cyclic structure<\/li>\n<li>Stable freeze-dried form<\/li>\n<li>Certificate of analysis for each batch<\/li>\n<\/ul>\n<h2><strong>Science FAQ<\/strong><\/h2>\n<h3><strong>1. What is Melanotan II and what is its structure?<\/strong><\/h3>\n<p>Melanotan II (MT-II) is a synthetic cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 and a molar mass of 1024.18 g\/mol. It is an analogue of \u03b1-MSH with a cyclic structure ensuring increased stability. It acts as a non-selective agonist of melanocortin receptors (MC1R-MC5R). The CAS number is 121062-08-6.<\/p>\n<h3><strong>2. What is the difference between Melanotan II and Melanotan I?<\/strong><\/h3>\n<p>Melanotan I (Afamelanotide) is a linear 13 AA peptide that is more selective for MC1R. Melanotan II is a cyclic heptapeptide, non-selective for MC1R-MC5R. MT-II has a smaller mass (~1024 vs. ~1646 Da) and has activity on a broader spectrum of receptors, including MC3R and MC4R in the CNS.<\/p>\n<h3><strong>3. Why does Melanotan II contain norleucine instead of methionine?<\/strong><\/h3>\n<p>Norleucine (Nle) replaces methionine (Met) present in natural \u03b1-MSH to avoid oxidation of the thioether group of methionine. Oxidized methionine (sulfoxide) loses its biological activity. Norleucine has similar hydrophobic properties but is stable to oxidation.<\/p>\n<h3><strong>4. What does &#8220;cyclic&#8221; mean in the context of a peptide structure?<\/strong><\/h3>\n<p>The cyclic structure of Melanotan II is formed by the formation of an amide bond between the aspartic acid side chain (Asp) and the lysine side chain (Lys). This cyclization creates a ring that stiffens the conformation of the peptide and increases its resistance to degradation by proteases.<\/p>\n<h3><strong>5. What research is Melanotan II used for?<\/strong><\/h3>\n<p>MT II is used in in vitro studies on: melanocortin receptors (MC1R-MC5R), cAMP\/PKA signaling pathways, the mechanics of melanogenesis, and as a standard in melanocortin structure-activity studies. It is not intended for use on humans or animals.<\/p>\n<h2><strong>The most important research conclusions<\/strong><\/h2>\n<p><strong>The most important features of the ONE Melanotan II 10 mg product:<\/strong><\/p>\n<ul>\n<li><strong>Type<\/strong> \u2013 cyclic \u03b1-MSH analogue<\/li>\n<li><strong>Sequence<\/strong> \u2013 Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2<\/li>\n<li><strong>Molar mass<\/strong> \u2013 1024.18 g\/mol<\/li>\n<li><strong>CAS number<\/strong> \u2013 121062-08-6<\/li>\n<li><strong>Receptors<\/strong> \u2013 MC1R-MC5R (non-selective)<\/li>\n<li><strong>Structure<\/strong> \u2013 cyclic (Asp-Lys lactone)<\/li>\n<li><strong>Cleanliness<\/strong> \u2013 minimum 98% HPLC<\/li>\n<li><strong>Form<\/strong> \u2013 lyophilisate (white powder)<\/li>\n<li><strong>Destiny<\/strong> \u2013 only in vitro tests<\/li>\n<\/ul>\n<section class=\"scientific-references\">\n<h3>Bibliography<\/h3>\n<ol>\n<li><strong>Hruby VJ, et al. (1995)<\/strong> &#8220;Structure-activity relationships of melanocortin peptide agonists&#8221; &#8211; Annals of the New York Academy of Sciences, 780:51-62.<br \/>\nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/8602756\/<\/li>\n<li><strong>Cone R.D. (2005)<\/strong> &#8220;Anatomy and regulation of the central melanocortin system&#8221; &#8211; Nature Neuroscience, 8(5):571-578.<br \/>\nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/15856065\/<\/li>\n<li><strong>Hadley M.E., Dorr R.T. (2006)<\/strong> &#8220;Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization&#8221; &#8211; Peptides, 27(4):921-930.<br \/>\nLink: https:\/\/pubmed.ncbi.nlm.nih.gov\/16412534\/<\/li>\n<\/ol>\n<\/section>\n<section class=\"scientific-references\">\n<h3>Chemical data source<\/h3>\n<ul>\n<li>PubChem. <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/92432\" target=\"_blank\" rel=\"noopener noreferrer\"><cite>Melanotan II, CID 92432<\/cite><\/a>.<\/li>\n<\/ul>\n<\/section>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Melanotan II and what is its structure?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Melanotan II (MT-II) is a synthetic cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 and a molar mass of 1024.18 g\/mol. It is an analogue of \u03b1-MSH with a cyclic structure ensuring increased stability. It acts as a non-selective agonist of melanocortin receptors (MC1R-MC5R). The CAS number is 121062-08-6.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is the difference between Melanotan II and Melanotan I?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Melanotan I (Afamelanotide) is a linear 13 AA peptide that is more selective for MC1R. Melanotan II is a cyclic heptapeptide, non-selective for MC1R-MC5R. MT-II has a smaller mass (~1024 vs. ~1646 Da) and has activity on a broader spectrum of receptors, including MC3R and MC4R in the CNS.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Why does Melanotan II contain norleucine instead of methionine?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Norleucine (Nle) replaces methionine (Met) present in natural \u03b1-MSH to avoid oxidation of the thioether group of methionine. Oxidized methionine (sulfoxide) loses its biological activity. Norleucine has similar hydrophobic properties but is stable to oxidation.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What does \\\"cyclic\\\" mean in the context of a peptide structure?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"The cyclic structure of Melanotan II is formed by the formation of an amide bond between the aspartic acid side chain (Asp) and the lysine side chain (Lys). This cyclization creates a ring that stiffens the conformation of the peptide and increases its resistance to degradation by proteases.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What research is Melanotan II used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"MT II is used in in vitro studies on: melanocortin receptors (MC1R-MC5R), cAMP\/PKA signaling pathways, the mechanics of melanogenesis, and as a standard in melanocortin structure-activity studies. It is not intended for use on humans or animals.\"\n      }\n    }\n  ]\n}\n<\/script><\/p>\n<p><!-- onep-product-reviewer-banner:start --><\/p>\n<div class=\"author-box onep-product-reviewer-banner\" style=\"border-left: 4px solid #958e09; background: #f9fafb; padding: 16px 20px; margin: 32px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0; font-size: 14px; line-height: 1.5;\"><strong>Pharmacological review:<\/strong> <a href=\"https:\/\/one-peptides.com\/team-aneta-kropicka\/\">MPharm Aneta Kropicka<\/a><br \/>\n<em>Pharmaceutical reviewer and sports supplementation expert.<\/em><br \/>\nMaster of Pharmacy with 12 years of professional experience, graduate of the Medical University of \u0141\u00f3d\u017a (2014). Verifies One Peptides product content for pharmacology, clinical dosing, and regulatory compliance across RUO \/ dietary supplement \/ drug frameworks.<\/p>\n<p style=\"margin: 0; font-size: 12px; color: #6b7280;\"><small>Published: <time datetime=\"2024-11-23\">2024-11-23<\/time> \u2022 Last updated: <time datetime=\"2026-07-09\">2026-07-09<\/time><\/small><\/p>\n<\/div>\n<p><!-- onep-product-reviewer-banner:end --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One Peptides Melanotan II 10 mg. Research Use Only (RUO). Chemical reagent for laboratory tests only. MT-II is a synthetic cyclic heptapeptide that is an analogue of the naturally occurring hormone \u03b1-melanotropin (\u03b1-MSH \u2013 \u03b1-Melanocyte Stimulating Hormone).<\/p>","protected":false},"featured_media":1128,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_members_access_role":[],"_members_access_error":""},"product_brand":[],"product_cat":[90,34],"product_tag":[],"class_list":["post-1012","product","type-product","status-publish","has-post-thumbnail","product_cat-melanotan","product_cat-peptides","first","instock","sale","shipping-taxable","purchasable","product-type-simple"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO Pro 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"One Peptides Melanotan II 10 mg. Research Use Only (RUO). Chemical reagent for laboratory tests only. 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